What's better: Amitriptyline vs Paroxetine?
Quality Comparison Report

Scoring is done by our AI based assistant on the data from the FDA and other sources


Paroxetine
From 18.73$
Active Ingredients
paroxetine
Drug Classes
Selective serotonin reuptake inhibitors
Effeciency between Amitriptyline vs Paroxetine?
When it comes to treating depression, two popular medications often come to mind: amitriptyline and paroxetine. But which one is more effective? Let's dive into the world of antidepressants and explore the efficiency between amitriptyline vs paroxetine.
Amitriptyline, a tricyclic antidepressant (TCA), has been around for decades and is known for its ability to target the brain's serotonin and norepinephrine levels. It's often prescribed for mild to moderate depression, and its efficiency in treating symptoms like insomnia and anxiety is well-documented. In fact, studies have shown that amitriptyline can be just as effective as paroxetine in reducing symptoms of depression, especially in patients with mild to moderate depression.
On the other hand, paroxetine, a selective serotonin reuptake inhibitor (SSRI), is a more modern medication that's specifically designed to target serotonin levels in the brain. It's often prescribed for moderate to severe depression, and its efficiency in treating symptoms like low mood and loss of interest in activities is well-established. While paroxetine may have a slightly faster onset of action compared to amitriptyline, its efficiency in treating depression is not significantly different from that of amitriptyline.
In head-to-head comparisons, amitriptyline vs paroxetine, both medications have been shown to be effective in treating depression. However, the efficiency of each medication can vary depending on the individual patient and their specific needs. For example, amitriptyline may be more effective for patients with mild to moderate depression, while paroxetine may be more effective for patients with moderate to severe depression. Ultimately, the choice between amitriptyline and paroxetine will depend on a patient's unique circumstances and the guidance of a healthcare professional.
Amitriptyline, a tricyclic antidepressant (TCA), has been around for decades and is known for its ability to target the brain's serotonin and norepinephrine levels. It's often prescribed for mild to moderate depression, and its efficiency in treating symptoms like insomnia and anxiety is well-documented. In fact, studies have shown that amitriptyline can be just as effective as paroxetine in reducing symptoms of depression, especially in patients with mild to moderate depression.
On the other hand, paroxetine, a selective serotonin reuptake inhibitor (SSRI), is a more modern medication that's specifically designed to target serotonin levels in the brain. It's often prescribed for moderate to severe depression, and its efficiency in treating symptoms like low mood and loss of interest in activities is well-established. While paroxetine may have a slightly faster onset of action compared to amitriptyline, its efficiency in treating depression is not significantly different from that of amitriptyline.
In head-to-head comparisons, amitriptyline vs paroxetine, both medications have been shown to be effective in treating depression. However, the efficiency of each medication can vary depending on the individual patient and their specific needs. For example, amitriptyline may be more effective for patients with mild to moderate depression, while paroxetine may be more effective for patients with moderate to severe depression. Ultimately, the choice between amitriptyline and paroxetine will depend on a patient's unique circumstances and the guidance of a healthcare professional.
Safety comparison Amitriptyline vs Paroxetine?
When it comes to comparing the safety of Amitriptyline vs Paroxetine, it's essential to consider the potential risks associated with each medication. Amitriptyline, a tricyclic antidepressant, has been linked to several safety concerns, including increased heart rate and blood pressure, as well as the potential for QT interval prolongation, which can lead to serious cardiac arrhythmias.
In contrast, Paroxetine, a selective serotonin reuptake inhibitor (SSRI), has also been associated with safety issues, such as an increased risk of suicidal thoughts and behaviors, particularly in young adults. Additionally, Paroxetine may cause a condition called serotonin syndrome, which can be life-threatening if left untreated.
Amitriptyline vs Paroxetine: which one is safer? While both medications have their own set of safety concerns, Amitriptyline has been shown to have a higher risk of adverse effects, particularly in older adults. Amitriptyline can cause a range of side effects, including dizziness, drowsiness, and dry mouth, which can be problematic for some patients.
Amitriptyline has also been linked to a higher risk of falls and fractures, particularly in older adults, due to its sedative effects. On the other hand, Paroxetine has been associated with a higher risk of gastrointestinal problems, such as nausea and vomiting, as well as headaches and fatigue.
In terms of safety, Amitriptyline vs Paroxetine, Amitriptyline has a black box warning for its potential to cause QT interval prolongation, which can increase the risk of cardiac arrhythmias. In contrast, Paroxetine has a black box warning for its potential to cause serotonin syndrome, which can be life-threatening if left untreated.
Overall, while both medications have their own set of safety concerns, Amitriptyline appears to have a higher risk of adverse effects, particularly in older adults. Amitriptyline's sedative effects can increase the risk of falls and fractures, while Paroxetine's potential for serotonin syndrome is a serious concern. When it comes to safety, Amitriptyline vs Paroxetine, it's essential to weigh the potential benefits against the potential risks and consult with a healthcare professional to determine the best course of treatment.
In contrast, Paroxetine, a selective serotonin reuptake inhibitor (SSRI), has also been associated with safety issues, such as an increased risk of suicidal thoughts and behaviors, particularly in young adults. Additionally, Paroxetine may cause a condition called serotonin syndrome, which can be life-threatening if left untreated.
Amitriptyline vs Paroxetine: which one is safer? While both medications have their own set of safety concerns, Amitriptyline has been shown to have a higher risk of adverse effects, particularly in older adults. Amitriptyline can cause a range of side effects, including dizziness, drowsiness, and dry mouth, which can be problematic for some patients.
Amitriptyline has also been linked to a higher risk of falls and fractures, particularly in older adults, due to its sedative effects. On the other hand, Paroxetine has been associated with a higher risk of gastrointestinal problems, such as nausea and vomiting, as well as headaches and fatigue.
In terms of safety, Amitriptyline vs Paroxetine, Amitriptyline has a black box warning for its potential to cause QT interval prolongation, which can increase the risk of cardiac arrhythmias. In contrast, Paroxetine has a black box warning for its potential to cause serotonin syndrome, which can be life-threatening if left untreated.
Overall, while both medications have their own set of safety concerns, Amitriptyline appears to have a higher risk of adverse effects, particularly in older adults. Amitriptyline's sedative effects can increase the risk of falls and fractures, while Paroxetine's potential for serotonin syndrome is a serious concern. When it comes to safety, Amitriptyline vs Paroxetine, it's essential to weigh the potential benefits against the potential risks and consult with a healthcare professional to determine the best course of treatment.
Users review comparison

Summarized reviews from the users of the medicine
My doctor started me on Amitriptyline for my depression, but honestly, it felt like I was walking through mud all the time. I was so tired! My doctor suggested trying Paroxetine, and it's been a lifesaver! I have more energy, and my mood is much more stable.
I was really struggling with both anxiety and depression, and Amitriptyline helped with the depression, but it made my anxiety worse. I couldn't handle the constant racing thoughts and feeling on edge. Paroxetine has been a much better choice. It's helped with both conditions without the anxiety flare-ups.
Side effects comparison Amitriptyline vs Paroxetine?
When considering the treatment options for depression, anxiety, or chronic pain, two medications often come up in conversation: Amitriptyline and Paroxetine. Both are commonly prescribed, but they have distinct side effect profiles. In this article, we'll delve into the side effects comparison of Amitriptyline vs Paroxetine to help you make an informed decision.
Amitriptyline is a tricyclic antidepressant (TCA) that has been used for decades to treat various conditions. However, its side effects can be a concern for some patients. Amitriptyline can cause drowsiness, dry mouth, and constipation, which may be problematic for those who need to take it during the day. Additionally, Amitriptyline can increase the risk of heart problems, especially in older adults or those with pre-existing heart conditions.
On the other hand, Paroxetine is a selective serotonin reuptake inhibitor (SSRI) that is often prescribed for depression, anxiety, and obsessive-compulsive disorder (OCD). While generally considered safer than Amitriptyline, Paroxetine can still cause side effects. Paroxetine can lead to nausea, headaches, and dizziness, especially when first starting the medication. In some cases, Paroxetine may also increase the risk of suicidal thoughts or behaviors, particularly in children and adolescents.
A key difference between Amitriptyline and Paroxetine is their potential for withdrawal symptoms. Amitriptyline can cause withdrawal symptoms like dizziness, headaches, and nausea when stopped abruptly. This is because the body becomes accustomed to the medication's effects, and sudden cessation can lead to these side effects. Paroxetine, on the other hand, may also cause withdrawal symptoms, but they are generally less severe.
Amitriptyline vs Paroxetine: which one is right for you? The answer depends on your individual needs and medical history. If you're looking for a medication with a faster onset of action, Amitriptyline may be a better choice. However, if you're concerned about the potential for side effects, Paroxetine might be a more suitable option. Ultimately, it's essential to discuss your treatment options with your doctor and weigh the benefits and risks of each medication.
When comparing the side effects of Amitriptyline and Paroxetine, it's essential to consider your overall health and medical history. Amitriptyline can be beneficial for those with chronic pain or fibromyalgia, but its side effects may be a concern for others. Paroxetine, while generally considered safer, may not be suitable for everyone, particularly those with a history of bleeding disorders or seizures.
In conclusion, the side effects comparison of Amitriptyline vs Paroxetine highlights the importance of careful consideration when choosing a medication. While both medications can be effective, their side effect profiles are distinct. By understanding the potential risks and benefits of each, you can make an informed decision about your treatment options.
Amitriptyline is a tricyclic antidepressant (TCA) that has been used for decades to treat various conditions. However, its side effects can be a concern for some patients. Amitriptyline can cause drowsiness, dry mouth, and constipation, which may be problematic for those who need to take it during the day. Additionally, Amitriptyline can increase the risk of heart problems, especially in older adults or those with pre-existing heart conditions.
On the other hand, Paroxetine is a selective serotonin reuptake inhibitor (SSRI) that is often prescribed for depression, anxiety, and obsessive-compulsive disorder (OCD). While generally considered safer than Amitriptyline, Paroxetine can still cause side effects. Paroxetine can lead to nausea, headaches, and dizziness, especially when first starting the medication. In some cases, Paroxetine may also increase the risk of suicidal thoughts or behaviors, particularly in children and adolescents.
A key difference between Amitriptyline and Paroxetine is their potential for withdrawal symptoms. Amitriptyline can cause withdrawal symptoms like dizziness, headaches, and nausea when stopped abruptly. This is because the body becomes accustomed to the medication's effects, and sudden cessation can lead to these side effects. Paroxetine, on the other hand, may also cause withdrawal symptoms, but they are generally less severe.
Amitriptyline vs Paroxetine: which one is right for you? The answer depends on your individual needs and medical history. If you're looking for a medication with a faster onset of action, Amitriptyline may be a better choice. However, if you're concerned about the potential for side effects, Paroxetine might be a more suitable option. Ultimately, it's essential to discuss your treatment options with your doctor and weigh the benefits and risks of each medication.
When comparing the side effects of Amitriptyline and Paroxetine, it's essential to consider your overall health and medical history. Amitriptyline can be beneficial for those with chronic pain or fibromyalgia, but its side effects may be a concern for others. Paroxetine, while generally considered safer, may not be suitable for everyone, particularly those with a history of bleeding disorders or seizures.
In conclusion, the side effects comparison of Amitriptyline vs Paroxetine highlights the importance of careful consideration when choosing a medication. While both medications can be effective, their side effect profiles are distinct. By understanding the potential risks and benefits of each, you can make an informed decision about your treatment options.
Contradictions of Amitriptyline vs Paroxetine?
Amitriptyline has been used to treat depression and certain types of chronic pain. However, it has several contradictions that make it less desirable for some patients. Amitriptyline can cause drowsiness, dry mouth, and constipation, which can be uncomfortable for some individuals.
On the other hand, Paroxetine is a selective serotonin reuptake inhibitor (SSRI) that is commonly used to treat depression, anxiety disorders, and obsessive-compulsive disorder. While it can be effective, Paroxetine has its own set of contradictions, including increased risk of suicidal thoughts in young adults and potential interactions with other medications.
When comparing Amitriptyline vs Paroxetine, it's essential to consider the specific needs and health status of the individual. Amitriptyline may be more suitable for patients with chronic pain, whereas Paroxetine might be a better option for those with anxiety disorders. Amitriptyline vs Paroxetine has been a topic of debate among healthcare professionals, with some arguing that Amitriptyline's side effects outweigh its benefits, while others claim that Paroxetine's risks are too great.
On the other hand, Paroxetine is a selective serotonin reuptake inhibitor (SSRI) that is commonly used to treat depression, anxiety disorders, and obsessive-compulsive disorder. While it can be effective, Paroxetine has its own set of contradictions, including increased risk of suicidal thoughts in young adults and potential interactions with other medications.
When comparing Amitriptyline vs Paroxetine, it's essential to consider the specific needs and health status of the individual. Amitriptyline may be more suitable for patients with chronic pain, whereas Paroxetine might be a better option for those with anxiety disorders. Amitriptyline vs Paroxetine has been a topic of debate among healthcare professionals, with some arguing that Amitriptyline's side effects outweigh its benefits, while others claim that Paroxetine's risks are too great.
Users review comparison

Summarized reviews from the users of the medicine
Ugh, Amitriptyline! It gave me the worst dry mouth I've ever experienced. It was so uncomfortable, and it made it hard to sleep. Paroxetine has been a vast improvement! I haven't had any problems with dryness or sleep, and it's working well for my depression.
I'm so glad I finally switched from Amitriptyline to Paroxetine! Amitriptyline made me feel so out of it, and I couldn't concentrate on anything. Paroxetine, on the other hand, has helped me feel more focused and alert. It's been a true game-changer for me, and I finally feel like I can enjoy life again!
Addiction of Amitriptyline vs Paroxetine?
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Daily usage comfort of Amitriptyline vs Paroxetine?
When it comes to daily usage comfort, Amitriptyline is often preferred over Paroxetine. Amitriptyline is a tricyclic antidepressant that has been used for decades to treat depression and certain types of pain. It's available in a variety of forms, including tablets and capsules, which can make it easier to take on a daily basis. Amitriptyline is generally considered to be a more comfortable medication to take, especially for people who have trouble swallowing pills.
However, Paroxetine is also a popular choice for daily usage. Paroxetine is a selective serotonin reuptake inhibitor (SSRI) that is commonly used to treat depression, anxiety, and other mental health conditions. It's available in a variety of forms, including tablets and liquid solutions, which can make it easier to take for people who have trouble swallowing pills. Paroxetine is often preferred by people who are looking for a medication that is easy to take on a daily basis and provides quick relief from symptoms.
Amitriptyline vs Paroxetine is a common debate among healthcare professionals and patients alike. When it comes to daily usage comfort, Amitriptyline is often considered to be the more comfortable option. This is because Amitriptyline has a longer half-life, which means that it stays in the system for a longer period of time. This can make it easier to take on a daily basis, as people don't have to worry about taking multiple doses throughout the day. Paroxetine, on the other hand, has a shorter half-life, which means that it needs to be taken more frequently.
In terms of comfort, Amitriptyline is often preferred because it has a more gentle effect on the body. Amitriptyline is a tricyclic antidepressant that works by affecting the levels of certain neurotransmitters in the brain. This can help to improve mood and reduce symptoms of depression and anxiety. Paroxetine, on the other hand, is an SSRI that works by increasing the levels of serotonin in the brain. While Paroxetine can be effective, it can also cause more side effects, such as nausea and dizziness, which can make it less comfortable to take.
For people who are looking for a medication that is easy to take on a daily basis and provides quick relief from symptoms, Amitriptyline vs Paroxetine is a good option to consider. While both medications have their own set of benefits and drawbacks, Amitriptyline is often considered to be the more comfortable option. This is because Amitriptyline has a longer half-life and a more gentle effect on the body, which can make it easier to take on a daily basis. However, it's always best to talk to a healthcare professional before starting any new medication, as they can help to determine the best course of treatment for individual needs.
However, Paroxetine is also a popular choice for daily usage. Paroxetine is a selective serotonin reuptake inhibitor (SSRI) that is commonly used to treat depression, anxiety, and other mental health conditions. It's available in a variety of forms, including tablets and liquid solutions, which can make it easier to take for people who have trouble swallowing pills. Paroxetine is often preferred by people who are looking for a medication that is easy to take on a daily basis and provides quick relief from symptoms.
Amitriptyline vs Paroxetine is a common debate among healthcare professionals and patients alike. When it comes to daily usage comfort, Amitriptyline is often considered to be the more comfortable option. This is because Amitriptyline has a longer half-life, which means that it stays in the system for a longer period of time. This can make it easier to take on a daily basis, as people don't have to worry about taking multiple doses throughout the day. Paroxetine, on the other hand, has a shorter half-life, which means that it needs to be taken more frequently.
In terms of comfort, Amitriptyline is often preferred because it has a more gentle effect on the body. Amitriptyline is a tricyclic antidepressant that works by affecting the levels of certain neurotransmitters in the brain. This can help to improve mood and reduce symptoms of depression and anxiety. Paroxetine, on the other hand, is an SSRI that works by increasing the levels of serotonin in the brain. While Paroxetine can be effective, it can also cause more side effects, such as nausea and dizziness, which can make it less comfortable to take.
For people who are looking for a medication that is easy to take on a daily basis and provides quick relief from symptoms, Amitriptyline vs Paroxetine is a good option to consider. While both medications have their own set of benefits and drawbacks, Amitriptyline is often considered to be the more comfortable option. This is because Amitriptyline has a longer half-life and a more gentle effect on the body, which can make it easier to take on a daily basis. However, it's always best to talk to a healthcare professional before starting any new medication, as they can help to determine the best course of treatment for individual needs.
Comparison Summary for Amitriptyline and Paroxetine?
When it comes to treating depression and anxiety, two medications often come up in conversation: amitriptyline and paroxetine. Both have their own set of benefits and drawbacks, making the comparison between the two a crucial one for those seeking effective treatment.
In the comparison of amitriptyline and paroxetine, it's essential to understand that amitriptyline is a tricyclic antidepressant (TCA) that has been around for decades. It works by increasing the levels of certain neurotransmitters in the brain, such as serotonin and norepinephrine, which helps to improve mood and reduce symptoms of depression. Amitriptyline is often prescribed for patients with major depressive disorder, chronic pain, and migraines. The amitriptyline dosage can vary depending on the individual's response to the medication and the severity of their symptoms.
On the other hand, paroxetine is a selective serotonin reuptake inhibitor (SSRI), a newer class of antidepressants. It also works by increasing the levels of serotonin in the brain, but it's more targeted in its approach. Paroxetine is commonly prescribed for patients with depression, anxiety disorders, and obsessive-compulsive disorder. The paroxetine dosage is typically started at a low dose and gradually increased as needed.
In the comparison of amitriptyline vs paroxetine, it's worth noting that both medications have their own set of potential side effects. Amitriptyline can cause drowsiness, dry mouth, and constipation, while paroxetine may lead to nausea, dizziness, and changes in appetite. In some cases, patients may experience more severe side effects, such as increased risk of suicidal thoughts or behaviors, especially when starting treatment with either medication.
A key aspect of the comparison between amitriptyline and paroxetine is their interaction with other medications. Amitriptyline can interact with a wide range of medications, including MAOIs, and may increase the risk of serotonin syndrome. Paroxetine, on the other hand, may interact with other SSRIs, MAOIs, and certain types of antidepressants, increasing the risk of serotonin syndrome.
In terms of the comparison between amitriptyline and paroxetine, it's also essential to consider their potential impact on pregnancy and breastfeeding. Amitriptyline has been linked to an increased risk of birth defects, and it's not recommended for pregnant women. Paroxetine has also been associated with an increased risk of birth defects, particularly heart defects, and it's recommended that women avoid taking it during pregnancy.
Ultimately, the comparison between amitriptyline and paroxetine highlights the importance of working closely with a healthcare provider to determine the best course of treatment. While both medications have their own set of benefits and drawbacks, the right choice for an individual will depend on their unique needs and medical history.
In the comparison of amitriptyline and paroxetine, it's essential to understand that amitriptyline is a tricyclic antidepressant (TCA) that has been around for decades. It works by increasing the levels of certain neurotransmitters in the brain, such as serotonin and norepinephrine, which helps to improve mood and reduce symptoms of depression. Amitriptyline is often prescribed for patients with major depressive disorder, chronic pain, and migraines. The amitriptyline dosage can vary depending on the individual's response to the medication and the severity of their symptoms.
On the other hand, paroxetine is a selective serotonin reuptake inhibitor (SSRI), a newer class of antidepressants. It also works by increasing the levels of serotonin in the brain, but it's more targeted in its approach. Paroxetine is commonly prescribed for patients with depression, anxiety disorders, and obsessive-compulsive disorder. The paroxetine dosage is typically started at a low dose and gradually increased as needed.
In the comparison of amitriptyline vs paroxetine, it's worth noting that both medications have their own set of potential side effects. Amitriptyline can cause drowsiness, dry mouth, and constipation, while paroxetine may lead to nausea, dizziness, and changes in appetite. In some cases, patients may experience more severe side effects, such as increased risk of suicidal thoughts or behaviors, especially when starting treatment with either medication.
A key aspect of the comparison between amitriptyline and paroxetine is their interaction with other medications. Amitriptyline can interact with a wide range of medications, including MAOIs, and may increase the risk of serotonin syndrome. Paroxetine, on the other hand, may interact with other SSRIs, MAOIs, and certain types of antidepressants, increasing the risk of serotonin syndrome.
In terms of the comparison between amitriptyline and paroxetine, it's also essential to consider their potential impact on pregnancy and breastfeeding. Amitriptyline has been linked to an increased risk of birth defects, and it's not recommended for pregnant women. Paroxetine has also been associated with an increased risk of birth defects, particularly heart defects, and it's recommended that women avoid taking it during pregnancy.
Ultimately, the comparison between amitriptyline and paroxetine highlights the importance of working closely with a healthcare provider to determine the best course of treatment. While both medications have their own set of benefits and drawbacks, the right choice for an individual will depend on their unique needs and medical history.
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