How does Synopsis AI work? How does rating work?
In this article, we will go over 18 parameters, resources, and methods of drug evaluation that we use. We won't go into details but will quickly explain them to give you an understanding.
Let's start with what our scales imply: "Effectiveness", "Contraindications", "Safety", "Addiction", and "Usage Comfort".
1. Effectiveness
Effectiveness
How quickly the drug acts and whether it works at all.
Therapeutic Effectiveness
The ability of a drug to exert the maximum possible effect. For example, if drug A can produce a therapeutic effect that cannot be achieved with drug B even at higher doses, then drug A has more pronounced therapeutic properties.
Speed of Therapy
The rate of therapeutic action.
Bioavailability
The amount of drug that reaches its site of action in the body. The higher the bioavailability, the fewer losses during absorption and utilization by the body.
Originality of the Drug
To enter the pharmaceutical market, a drug undergoes a series of preclinical and clinical trials. An original drug is granted a patent for an average of 20 years. During this period, reproduction of the molecule is prohibited. After the patent expires, generics appear. Responsible companies refine the drug and conduct their own clinical trials. Irresponsible ones simply copy the original molecule.
2. Safety
Safety
Which organ is affected by taking the drug. Is it worth taking the drug at all or is it better to replace it with good bed rest?
Where it Metabolizes
Drugs are excreted from the body either unchanged or as products of their biochemical transformations. Metabolism can occur spontaneously, but most often it is catalyzed by enzymes localized in the membranes of cells and cell organelles of the liver, kidneys, lungs, skin, brain, and others. To assess, we look at which organ metabolizes the drug and how critical its action is.
Risk-to-Benefit Ratio
The prescription of a drug is undesirable but justified under certain conditions and circumstances, with mandatory caution in use.
Reversibility of Consequences
In any case, there are no completely safe drugs; even small effects of the drug influence the body, which needs time to recover from the use, if possible. That is, are the consequences reversible and how quickly?
Impact on the Body
Manifestation of only allergic reactions or possible dysfunction of major organs.
3. Addiction
Addiction
Does dependency on the drug form? Does the dose need to be increased each time?
Withdrawal Syndrome
A pathological condition that occurs after the cessation of substances that cause addiction or dependence.
Increase in Dose
The need for a constant increase in the therapeutic dose to achieve the effect.
Development of Resistance
Resistance is understood as initial insensitivity to the drug, which differs from addiction when insensitivity develops over a period. Resistance can be stated only if there was an attempt to increase the dose of the drug to the maximum possible.
4. Usage Comfort
Usage Comfort
How is the dosage selected, does the drug need to be used systematically and frequently, or can it be used rarely? Does it require injections or just taking a pill?
Dose Adjustment
Selection of the dose considering various conditions: external and internal.
Frequency of Administration
How often the drug needs to be taken, consumer convenience.
Form of Drug Administration
The possibility of self-administration without assistance, ease of use in daily life.
5. Contraindications
Contraindications
What are the undesirable effects and how do they manifest?
Frequency of Occurrence
Indicator of how many cases of undesirable effects from treatment are possible and recorded.
Severity
The undesirable impact on the body, the strength of the impact, and the toxic action afterward. How quickly the body recovers after use and whether it recovers at all.
Post-Marketing Studies
Research on international reports of undesirable effects of drugs after the start of mass sales and use.
Based on Instructions
A list of symptoms, syndromes, diseases, external and internal conditions under which the use of a specific drug may be undesirable or unacceptable.
Research
Review of FDA, PubMed, Cochrane studies. Searching for real contraindications based on clinical studies.