Both Vyvanse and Diphenhydramine offer similar effectiveness, with differences in speed and duration of relief.

Vyvanse has fewer side effects and is less likely to interact with other medications.

Vyvanse has a lower risk of addiction, making it safer for patients concerned about dependency.

Diphenhydramine offers various forms, including liquid and injectable options, providing more flexibility.

Diphenhydramine is safer for patients with cardiovascular issues or diabetes.

Both drugs are good options depending on the patient’s needs, with Vyvanse better for quick relief and Diphenhydramine for long-term management.