Both Tylenol and Diphenhydramine offer similar effectiveness, with differences in speed and duration of relief.

Tylenol has fewer side effects and is less likely to interact with other medications.

Both drugs are low-risk for addiction when used properly, with minimal potential for misuse.

Both drugs are easy to use, with clear dosing schedules to ensure treatment adherence.

Both drugs have some contraindications depending on individual health conditions, but neither has major restrictions.

Both drugs are good options depending on the patient’s needs, with Tylenol better for quick relief and Diphenhydramine for long-term management.