Both Trintellix and Xanax XR offer similar effectiveness, with differences in speed and duration of relief.

Trintellix has fewer side effects and is less likely to interact with other medications.

Xanax XR has a more stable effect and is less likely to lead to addiction over time.

Trintellix has a simple once-daily dose, making it easier to stick to a treatment routine.

Both drugs have some contraindications depending on individual health conditions, but neither has major restrictions.

Both drugs are good options depending on the patient’s needs, with Trintellix better for quick relief and Xanax XR for long-term management.