Both Sertraline and Wellbutrin XL offer similar effectiveness, with differences in speed and duration of relief.

Both drugs have comparable safety profiles, with mild side effects that are generally well-tolerated.

Wellbutrin XL has a more stable effect and is less likely to lead to addiction over time.

Both drugs are easy to use, with clear dosing schedules to ensure treatment adherence.

Both drugs have some contraindications depending on individual health conditions, but neither has major restrictions.

Both drugs are good options depending on the patient’s needs, with Sertraline better for quick relief and Wellbutrin XL for long-term management.