Both Prazosin and Seroquel offer similar effectiveness, with differences in speed and duration of relief.

Prazosin has fewer side effects and is less likely to interact with other medications.

Seroquel has a more stable effect and is less likely to lead to addiction over time.

Prazosin has a simple once-daily dose, making it easier to stick to a treatment routine.

Both drugs have some contraindications depending on individual health conditions, but neither has major restrictions.

Prazosin is ideal for fast relief, ease of use, and lower addiction risk, making it best for acute symptoms.