Both Pepto-Bismol and Seroquel offer similar effectiveness, with differences in speed and duration of relief.

Pepto-Bismol has fewer side effects and is less likely to interact with other medications.

Seroquel has a more stable effect and is less likely to lead to addiction over time.

Pepto-Bismol has a simple once-daily dose, making it easier to stick to a treatment routine.

Both drugs have some contraindications depending on individual health conditions, but neither has major restrictions.

Pepto-Bismol is ideal for fast relief, ease of use, and lower addiction risk, making it best for acute symptoms.