Both Nitrofurantoin and Methotrexate offer similar effectiveness, with differences in speed and duration of relief.

Both drugs have comparable safety profiles, with mild side effects that are generally well-tolerated.

Methotrexate has a more stable effect and is less likely to lead to addiction over time.

Both drugs are easy to use, with clear dosing schedules to ensure treatment adherence.

Both drugs have some contraindications depending on individual health conditions, but neither has major restrictions.

Both drugs are good options depending on the patient’s needs, with Nitrofurantoin better for quick relief and Methotrexate for long-term management.