Both Methadone and Methotrexate offer similar effectiveness, with differences in speed and duration of relief.

Methotrexate is gentler on the liver and kidneys, making it a safer long-term option for some patients.

Both drugs are low-risk for addiction when used properly, with minimal potential for misuse.

Both drugs are easy to use, with clear dosing schedules to ensure treatment adherence.

Methotrexate is safer for patients with cardiovascular issues or diabetes.

Both drugs are good options depending on the patient’s needs, with Methadone better for quick relief and Methotrexate for long-term management.