Both L-methylfolate and Acitretin offer similar effectiveness in symptom control, with the main difference being how quickly they act. Either drug is a viable option depending on the patient’s needs.

L-methylfolate has fewer side effects and is less likely to interact with other medications, making it a safer choice for sensitive patients.

Acitretin has a more stable therapeutic effect and is less likely to lead to dependency or cravings compared to L-methylfolate.

L-methylfolate offers the convenience of a once-daily dose, simplifying treatment adherence for patients.

Both L-methylfolate and Acitretin have some contraindications based on individual health conditions, but neither has significantly more restrictions than the other.

Both drugs offer advantages depending on treatment goals. L-methylfolate is great for fast relief, while Acitretin is better for long-term management. The choice depends on the patient’s specific needs.