Both Hydroxyzine and Diphenoxylate offer similar effectiveness in symptom control, with the main difference being how quickly they act. Either drug is a viable option depending on the patient’s needs.

Hydroxyzine has fewer side effects and is less likely to interact with other medications, making it a safer choice for sensitive patients.

Diphenoxylate has a more stable therapeutic effect and is less likely to lead to dependency or cravings compared to Hydroxyzine.

Hydroxyzine offers the convenience of a once-daily dose, simplifying treatment adherence for patients.

Diphenoxylate is better for patients with cardiovascular or diabetes-related issues, as it has fewer interactions with other medications.

Both drugs offer advantages depending on treatment goals. Hydroxyzine is great for fast relief, while Diphenoxylate is better for long-term management. The choice depends on the patient’s specific needs.