Both Guanfacine and Methylphenidate offer similar effectiveness in symptom control, with the main difference being how quickly they act. Either drug is a viable option depending on the patient’s needs.

Guanfacine has fewer side effects and is less likely to interact with other medications, making it a safer choice for sensitive patients.

Methylphenidate has a more stable therapeutic effect and is less likely to lead to dependency or cravings compared to Guanfacine.

Both Guanfacine and Methylphenidate are easy to use, with straightforward dosing regimens that ensure good adherence.

Both Guanfacine and Methylphenidate have some contraindications based on individual health conditions, but neither has significantly more restrictions than the other.

Methylphenidate is better suited for chronic conditions, offering longer-lasting effects and a favorable safety profile for long-term use. Its flexibility in administration makes it a strong option for various patient needs.