Both Fluoxetine and Trintellix offer similar effectiveness in symptom control, with the main difference being how quickly they act. Either drug is a viable option depending on the patient’s needs.

Both Fluoxetine and Trintellix have similar safety profiles, with mild and transient side effects. Neither presents significant long-term safety concerns.

Fluoxetine has a lower risk of dependency, making it a safer option for patients concerned about addiction.

Both Fluoxetine and Trintellix are easy to use, with straightforward dosing regimens that ensure good adherence.

Both Fluoxetine and Trintellix have some contraindications based on individual health conditions, but neither has significantly more restrictions than the other.

Both drugs offer advantages depending on treatment goals. Fluoxetine is great for fast relief, while Trintellix is better for long-term management. The choice depends on the patient’s specific needs.