Both Estradiol and Mirtazapine offer similar effectiveness in symptom control, with the main difference being how quickly they act. Either drug is a viable option depending on the patient’s needs.

Both Estradiol and Mirtazapine have similar safety profiles, with mild and transient side effects. Neither presents significant long-term safety concerns.

Both Estradiol and Mirtazapine have a low risk of addiction when used correctly under medical supervision, with minimal potential for misuse.

Estradiol offers the convenience of a once-daily dose, simplifying treatment adherence for patients.

Both Estradiol and Mirtazapine have some contraindications based on individual health conditions, but neither has significantly more restrictions than the other.

Estradiol is ideal for patients needing quick relief and higher potency. It’s easier to use, safer for most patients, and has a lower addiction risk, making it a top choice for acute symptoms.