Both Esomeprazole and Sodium bicarbonate offer similar effectiveness, with differences in speed and duration of relief.

Both drugs have comparable safety profiles, with mild side effects that are generally well-tolerated.

Both drugs are low-risk for addiction when used properly, with minimal potential for misuse.

Both drugs are easy to use, with clear dosing schedules to ensure treatment adherence.

Both drugs have some contraindications depending on individual health conditions, but neither has major restrictions.

Both drugs are good options depending on the patient’s needs, with Esomeprazole better for quick relief and Sodium bicarbonate for long-term management.