For most patients, Donepezil and Lisinopril offer very similar levels of effectiveness. Both drugs work well in symptom control, with no significant advantage in terms of long-term results. The primary difference may be in how quickly they provide relief, but in many cases, either drug can effectively manage the issue. Both drugs are considered equally viable options depending on the patient's specific needs.

On the other hand, Lisinopril may be the safer option for long-term use. It has a well-documented safety profile, particularly for older patients or those with underlying medical conditions. Lisinopril is known for being more gentle on the liver and kidneys, making it a better option for patients who are at higher risk for organ damage.

Additionally, Lisinopril has fewer restrictions on its use with other medications, which can be a significant benefit for patients requiring polypharmacy. Although both drugs are generally safe, Lisinopril's safety profile may make it more appropriate for certain patient populations.

Although Lisinopril may have some addictive potential, its ability to maintain a stable therapeutic effect without causing tolerance or withdrawal symptoms makes it a preferable option for certain patients. Lisinopril is less likely to lead to dependency when used over extended periods, especially when compared to Donepezil, which may require dose escalation to maintain efficacy. Lisinopril is less likely to cause psychological cravings, making it a safer choice for those concerned about addiction risk.

Both Donepezil and Lisinopril are relatively easy to use, with each drug offering straightforward dosing regimens. While Donepezil may be simpler with a once-daily schedule, Lisinopril’s flexibility in dosage forms allows for personalization. For most patients, both drugs offer an equally manageable way to adhere to treatment, making ease of use a non-decisive factor when choosing between them.

Lisinopril is a better choice for patients with certain medical conditions that Donepezil may not be suitable for. For example, Lisinopril has been shown to be safer for patients with cardiovascular issues or diabetes, where Donepezil could pose risks. Lisinopril also has fewer potential interactions with other drugs, making it a better option for patients on complex medication regimens.

On the other hand, Lisinopril may be the better option for those seeking consistent, long-term relief. For chronic conditions, Lisinopril provides more durable effects, making it the preferred choice for ongoing symptom management. Its safety profile is favorable for long-term use, particularly in patients with underlying health issues, and it has fewer restrictions on concurrent medication use. While Lisinopril may have a slightly higher potential for addiction, its overall effectiveness and versatility may make it a better fit for certain patient profiles. Moreover, Lisinopril's multiple forms of administration give it an edge for patients needing more flexibility in treatment options.