Both Diphenhydramine and Plaquenil offer similar effectiveness in symptom control, with the main difference being how quickly they act. Either drug is a viable option depending on the patient’s needs.

Both Diphenhydramine and Plaquenil have similar safety profiles, with mild and transient side effects. Neither presents significant long-term safety concerns.

Both Diphenhydramine and Plaquenil have a low risk of addiction when used correctly under medical supervision, with minimal potential for misuse.

Both Diphenhydramine and Plaquenil are easy to use, with straightforward dosing regimens that ensure good adherence.

Diphenhydramine has fewer contraindications, making it suitable for a broader range of patients, including those with comorbidities.

Both drugs offer advantages depending on treatment goals. Diphenhydramine is great for fast relief, while Plaquenil is better for long-term management. The choice depends on the patient’s specific needs.