Both Diphenhydramine and Naproxen offer similar effectiveness, with differences in speed and duration of relief.

Naproxen is gentler on the liver and kidneys, making it a safer long-term option for some patients.

Both drugs are low-risk for addiction when used properly, with minimal potential for misuse.

Both drugs are easy to use, with clear dosing schedules to ensure treatment adherence.

Both drugs have some contraindications depending on individual health conditions, but neither has major restrictions.

Both drugs are good options depending on the patient’s needs, with Diphenhydramine better for quick relief and Naproxen for long-term management.