Diphenoxylate offers more sustained relief, making it better for chronic conditions. Its effects last longer, making it the better choice for long-term treatment.

Both Dimetapp and Diphenoxylate have similar safety profiles, with mild and transient side effects. Neither presents significant long-term safety concerns.

Diphenoxylate has a more stable therapeutic effect and is less likely to lead to dependency or cravings compared to Dimetapp.

Dimetapp offers the convenience of a once-daily dose, simplifying treatment adherence for patients.

Diphenoxylate is better for patients with cardiovascular or diabetes-related issues, as it has fewer interactions with other medications.

Both drugs offer advantages depending on treatment goals. Dimetapp is great for fast relief, while Diphenoxylate is better for long-term management. The choice depends on the patient’s specific needs.