Both Clonidine and Methadone offer similar effectiveness, with differences in speed and duration of relief.

Clonidine has fewer side effects and is less likely to interact with other medications.

Both drugs are low-risk for addiction when used properly, with minimal potential for misuse.

Clonidine has a simple once-daily dose, making it easier to stick to a treatment routine.

Both drugs have some contraindications depending on individual health conditions, but neither has major restrictions.

Clonidine is ideal for fast relief, ease of use, and lower addiction risk, making it best for acute symptoms.