Leflunomide offers more sustained relief, making it better for chronic conditions. Its effects last longer, making it the better choice for long-term treatment.

Both Cholestyramine and Leflunomide have similar safety profiles, with mild and transient side effects. Neither presents significant long-term safety concerns.

Leflunomide has a more stable therapeutic effect and is less likely to lead to dependency or cravings compared to Cholestyramine.

Both Cholestyramine and Leflunomide are easy to use, with straightforward dosing regimens that ensure good adherence.

Both Cholestyramine and Leflunomide have some contraindications based on individual health conditions, but neither has significantly more restrictions than the other.

Cholestyramine is ideal for patients needing quick relief and higher potency. It’s easier to use, safer for most patients, and has a lower addiction risk, making it a top choice for acute symptoms.