Both Bupropion and Tranylcypromine offer similar effectiveness, with differences in speed and duration of relief.

Bupropion has fewer side effects and is less likely to interact with other medications.

Tranylcypromine has a more stable effect and is less likely to lead to addiction over time.

Bupropion has a simple once-daily dose, making it easier to stick to a treatment routine.

Tranylcypromine is safer for patients with cardiovascular issues or diabetes.

Both drugs are good options depending on the patient’s needs, with Bupropion better for quick relief and Tranylcypromine for long-term management.