Both Bupropion and Melatonin offer similar effectiveness in symptom control, with the main difference being how quickly they act. Either drug is a viable option depending on the patient’s needs.

Melatonin is gentler on the liver and kidneys and has a better safety profile for long-term use, particularly for older patients or those with pre-existing conditions.

Both Bupropion and Melatonin have a low risk of addiction when used correctly under medical supervision, with minimal potential for misuse.

Melatonin offers greater flexibility with different delivery forms, making it suitable for patients with specific preferences or medical needs.

Both Bupropion and Melatonin have some contraindications based on individual health conditions, but neither has significantly more restrictions than the other.

Melatonin is better suited for chronic conditions, offering longer-lasting effects and a favorable safety profile for long-term use. Its flexibility in administration makes it a strong option for various patient needs.