Duloxetine offers more sustained relief, making it better for chronic conditions. Its effects last longer, making it the better choice for long-term treatment.

Duloxetine is gentler on the liver and kidneys and has a better safety profile for long-term use, particularly for older patients or those with pre-existing conditions.

Both Benzonatate and Duloxetine have a low risk of addiction when used correctly under medical supervision, with minimal potential for misuse.

Duloxetine offers greater flexibility with different delivery forms, making it suitable for patients with specific preferences or medical needs.

Both Benzonatate and Duloxetine have some contraindications based on individual health conditions, but neither has significantly more restrictions than the other.

Both drugs offer advantages depending on treatment goals. Benzonatate is great for fast relief, while Duloxetine is better for long-term management. The choice depends on the patient’s specific needs.