Both Benadryl Allergy and Paxil offer similar effectiveness, with differences in speed and duration of relief.

Benadryl Allergy has fewer side effects and is less likely to interact with other medications.

Paxil has a more stable effect and is less likely to lead to addiction over time.

Benadryl Allergy has a simple once-daily dose, making it easier to stick to a treatment routine.

Both drugs have some contraindications depending on individual health conditions, but neither has major restrictions.

Both drugs are good options depending on the patient’s needs, with Benadryl Allergy better for quick relief and Paxil for long-term management.